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The Needle At Your Dentist To Be Replaced Soon?
Posted by soumya | Posted in What's New!! | Posted on 02-07-2010
Researchers at Alzheimer’s Research Center at Region’s hospital, Minnesota, US have recently demonstrated that intranasally delivered local anaesthetic ( LA ) can cause complete anaesthesia of the teeth, TMJ ( Temporo mandibular joint) and the masseter muscle thus removing the need to use a needle to deliver the LA.
The concentrations of LA where delivered intra-nasally are 20 times in the region supplied by trigeminal nerve compared to the blood or brain, thus suggesting that intra-nasal administration of LA bypassing the blood brain barrier to reach the targeted area. The trigeminal nerve acts as a conduit to transport drug from the nasal cavity to the orofacial structures in addition to the brain. The study also showed that absorption of LA into the trigeminal nerve mostly occurs in the inner walls of the nose and the maxillary sinus.
In conclusion, intra-nasal delivery of LA to the trigeminal nerve and connected orofacial structures may provide a more effective and targeted method of treating postoperative dental pain/anxiety, trigeminal neuralgia, migraine, dementia and vaccinating against diseases.
For full research text CLICK HERE
